Page 10 - Mouse Molecular Genetics

Plenary/Platform Sessions
10
Tuesday, October 2 7:00 pm–10:40 pm
Merrill Hall
Plenary/Platform Session 1 -
Models of Human Disease
Chair: Lee Niswander, University of Colorado School of
Medicine
1
- 7:00
Exploring Neural Tube Closure via Genes,
Environment, and Imaging. Lee Niswander
.
Pediatrics,
Univ of Colorado School of Medicine, Aurora, CO.
2
- 7:30
A gene within the modifier locus,
Tgfbm3
,
regulates
signal transduction
via
TGF-β type I receptor to
modify vascular phenotypes in mice and in HHT
patients.
Kyoko Kawasaki
1
,
Sylvia Espejel
1
,
Tom
Letteboer
1,2
,
Michael Benzinou
1
,
Marie Lee
1
,
Ritu Roy
1
,
Hans Kristian Ploos van Amstel
2
,
Cornelius
Westermann
3
,
Rosemary Akhurst
1
. 1)
HDFCCC, UCSF,
San Francisco, CA; 2) Department of Medical Genetics,
University Medical Centre, Utrecht, The Netherlands; 3)
St. Antonius Ziekenhuis, Nieuwegein The Netherlands.
3
- 7:50
Phenotypic and Molecular Analyses of
Different
vangl2
Mutants Demonstrates Dominant
Effects of the
Looptail
Mutation during Hair Cell
Development.
Haifeng Yin, Catherine Copley,
Michael
Deans
.
Dept. of Otolaryngology/HNS, Johns Hopkins
University School of Medicine, Baltimore, MD.
4
- 8:10
Host Resistance To A Gastrointestinal Parasite
Regulated By A SNP Modulating SMAD3 Binding To
A TGFβ-Responsive Transcriptional Enhancer Of
Mina. Mark Bix
1,3
,
Meenu Pillai
1,3
,
Shangli Lian
1
,
Peter
Vogel
1
,
Mathew Coleman
2
,
Peter Ratcliffe
2
. 1)
Immunology, St. Jude Children's Research Hospital,
Memphis, TN; 2) Oxford University, Oxford, UK; 3)
Equal contribution.
5
- 8:30
Discovering genes and pathways involved in naevus
and melanoma development using the Collaborative
Cross. Graeme Walker
1
,
Ramesh Ram
2
,
Blake
Ferguson
1
,
Herlina Handoko
1
,
Peter Soyer
3
,
Grant
Morahan
2
. 1)
Skin Carcinogenesis Lab, QIMR, Brisbane,
Qld, Australia; 2) Centre for Diabetes Research, WAIMR,
The University of Western Australia, Perth, Australia; 3)
Dermatology Research Centre, UQ School of Medicine,
Brisbane QLD.
8:50
pm -
Break
6
- 9:10
The (uro)chordate-specific
Gumby
gene governs
angiogenesis and modulates Wnt signaling.
Elena
Rivkin
1,2
,
Stephanie M. Almeida
1,2
,
Teresa A. MacLean
1,2
,
Gang Xie
1
,
Sabine P. Cordes
1,2
. 1)
Samuel Lunenfeld
Research Institute, Toronto, Ontario, Canada; 2)
Department of Molecular Genetics, University of
Toronto, 1 King’s Crescent, Toronto, ON Canada.
7
- 9:30
Molecular pathogenesis of Joubert Syndrome and
related disorders. Tamara Caspary
1
,
Holden
Higginbotham
2
,
Laura E. Mariani
1,3
,
Tae-Yeon Eom
2
,
Miao Sun
1
,
Vanessa L. Horner
1
,
Alyssa B. Long
1
,
Eva S.
Anton
2
. 1)
Dept. of Human Genetics, Emory University
School of Medicine, Atlanta, GA; 2) The UNC
Neuroscience Center, The University of North Carolina
School of Medicine, Chapel Hill, NC; 3) Graduate
Program in Neuroscience, Emory University, Atlanta,
GA.
8
- 9:50
Genetic analysis of Down syndrome in mice.
Chunhong
Liu
1
,
Masae Morishima
2
,
Li Zhang
1
,
Xiaoling Jiang
1
,
Kai
Meng
1
,
Annie Pao
1
,
Michael Parmacek
3
,
Ping Ye
4
,
William Mobley
5
,
Allan Bradlley
6
,
Yuejin E. Yu
1
. 1)
Genetics Program, Roswell Park Cancer Institute,
Buffalo, NY; 2) Department of Anatomy and
Developmental Biology, Tokyo Women's Medical
University, Tokyo, Japan; 3) Cardiovascular Institute,
University of Pennsylvania, Philadelphia, PA; 4) School
of Molecular Bioscinces, Washington State University,
Pullman, WA; 5) Department of Neuroscinces, University
of California, San Diego, La Jolla, CA; 6) Wellcome
Trust Sanger Institute, Hixton, Cambridge, UK.
9
- 10:10
CHD5: Chromosome engineering, chromatin
dynamics, and cancer. Alea A. Mills
.
Cold Spring
Harbor Laboratory, Cold Spring Harbor, NY.